Senior Research Chemist

at  Convergent Research

Parallel Squared Technology Institute (PTI) is a non-profit research institute aiming to catalyze a leap in protein analysis technology and use it to explore new biological frontiers. PTI supports open research and educational opportunities supporting rapid career development for scientists, engineers, and mathematicians.
Why? Protein dysfunctions directly cause many diseases, such as Alzheimer’s disease. Yet, proteins remain understudied because of technological hurdles.
How? To resolve these limitations, PTI will develop mass tags enabling a new framework for multiplexed protein analysis by mass spectrometry towards achieving 100-fold increase in throughput. Scientists at and collaborating with the institute will use these gains to directly investigate disease mechanisms and resolve problems that have proven intractable for decades. Our proof of principle technology and strategies are outlined at: parallelsq.org.

SUMMARY OF POSITION

We are looking for an individual contributor who has experience modifying and functionalizing small molecules for protein modifications and/or degradation. This position will involve the investigation and development of mass tags for proteomic analysis. The successful candidate will work in a team environment with other scientists. In order to be seriously considered for this position, we require a cover letter as part of the candidate’s application.

QUALIFICATIONS:

• PhD in Chemistry or Chemical Biology, or related field.
• Experience in synthesizing small molecules for protein modification.
• Strong quantitative and analytical skills, with a proclivity for reasoning from first principles.
• Highly motivated and organized researcher with strong analytical and coding skills.

PREFERRED QUALIFICATIONS:

• Experience with mass spectrometry proteomics data analysis.
• Experience working with isotopes of carbon, nitrogen, oxygen, and hydrogen.

• Design and synthesize small molecules for protein modification.
• Define new directions for technology development that can unlock new testable hypotheses.
• Collaborate with other scientists to use machine learning and other computational approaches to learn principles for mass tag design.
• Mentor scientists and research associates.
• Prepare internal reports and manuscripts as well as present results at internal or external scientific meetings as appropriate.
• Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.
• Other duties as assigned.