Senior Scientist/Associate Director

at  Frontage Laboratories

SENIOR SCIENTIST/PRINCIPAL SCIENTIST/ASSOCIATE DIRECTOR – DMPK

Job Title: Senior Scientist/Principal Scientist/Associate Director – DMPK
Location: Exton, Pennsylvania
Department: Drug Metabolism and Pharmacokinetics (DMPK)
Reports to: Assistant VP
Full Time
Frontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.

JOB DESCRIPTION:

We are seeking an experienced and highly motivated Senior Scientist, Principal Scientist, or Associate Director to join our DMPK team. This position offers the opportunity to work in a dynamic environment that supports drug discovery and development programs.

QUALIFICATIONS:

• PhD in Biochemistry, Pharmacology, Chemistry, or a related field with 5-10+ years of relevant experience, or a Master’s degree with 10-15+ years of experience in DMPK, ADME, or a related field.
• Significant experience in leading ADME studies, particularly with radiolabeled compounds.
• Proven leadership experience in managing teams and delivering on tight deadlines while maintaining high standards of data quality.
• Excellent communication and leadership skills, with the ability to collaborate effectively across functions and levels.
• Familiarity with GLP compliance and EPA rules/regulations is a plus.

• Conduct in vitro and in vivo ADME studies using radiolabeled and non-radiolabeled compounds.
• Perform sample analysis using a range of analytical instruments, including sample oxidizers, liquid scintillation counting (LSC), and LC/MS.
• Manage labs to ensure proper instrument maintenance and documentation of equipment/instruments usage, calibration, and services.
• Prepare study protocols, oversee study conduct, collect and summarize data, and write/review reports to meet study timelines.
• Ensure all lab operations and record-keeping are of high quality and compliant with Frontage SOPs, DMPK guidelines, study protocol and applicable regulations.
• Manage multiple tasks/projects simultaneously to meet internal/external deadlines, fostering collaboration within the DMPK team.
• Provide training and mentorship to junior scientists in key areas of drug development.
• Demonstrate expertise in leading cross-functional, matrix-based project teams, taking accountability and guiding them to successful outcomes.
• Provide scientific leadership and direction to clients and development teams for ongoing and prospective programs.