Senior Scientist Medicinal Chemistry (m/f/d)

at  Indivumed GmbH

Indivumed Therapeutics is a biotech company focused on precision oncology. We look back on over twenty years of innovation, driven by a vision that remains unchanged to this day: To enable precision therapy that offers a cure for every cancer patient.
Striving for this goal we have unlocked an understanding of the molecular reality of cancer at an unparalleled level that is now supporting the identification of novel targets to partner with the pharmaceutical industry to develop precision cancer therapeutics.
Whether as a scientist or a mathematician, as a data analyst, or in a corporate function, there are many ways you can contribute to our purpose. As a visionary, international company, we provide ample opportunities for your professional advancement and career development along the way.
Join us in shaping the path to precision cancer therapy.
Your Responsibilities

As a member of our Biomathematics department you will work closely together with physicists, mathematicians and bioinformaticians and will be responsible fo designing and leading the chemical and bio-physical activities in the areas of hit identification, hit expansion/refinement as well as lead identification. From the target characterisation department, you obtain validated cancer treatment protein targets for which biochemical screening assays have been established. Your group has the following tasks

• Prepare protein targets for virtual ligand screening
• Select libraries for virtual screening
• Prepare the ligands for virtual screening
• Perform and supervised the virtual docking search and create a docking-score ranked list of compounds
• Discuss validation experiment setup with target characterisation group
• Analyse results from this group
• Design and perform hit refinement and lead identification, design experiments with target characterisation group and analyse their results
• Contribute to hit and lead patenting

Our Requirements

• PhD in chemistry or medicinal chemistry
• Minimum 5 years of experience in academic or corporate medicinal chemistry with a focus onthe following methods: (i.) Hit identification: Target protein preparation from X-ray structure, library selection or sampling, ligand preparation, docking algorithm result evaluation. (ii.) Hit expansion and lead generation from hits.
• Excellent skills in English, at least good oral and written skills in German (native speaker required in neither)

Your benefits

• Demanding area of responsibility in a fast-growing company
• Grant for the HVV ProfiTicket/Deutschlandticket
• Subsidy for sports membership and events
• Company pension scheme
• Company doctor
• Fresh fruits and drinks
• Christmas and summer party
• Flexible working hours
• German and English courses
• 30 days holiday
• The 24th and 31st of December are holidays and won´t be deducted from your annual holidays.

Would You Like to Contribute to the Success of Our Company?
Please apply online and include your salary expectations and current notice period

• Prepare protein targets for virtual ligand screening
• Select libraries for virtual screening
• Prepare the ligands for virtual screening
• Perform and supervised the virtual docking search and create a docking-score ranked list of compounds
• Discuss validation experiment setup with target characterisation group
• Analyse results from this group
• Design and perform hit refinement and lead identification, design experiments with target characterisation group and analyse their results
• Contribute to hit and lead patentin