Senior Scientist – Particle Engineering

at  AstraZeneca

ACCOUNTABILITIES:

As a Senior Scientist, you will contribute to complex projects focusing on sustainable process development and manufacture of drug substances. You will provide crystallisation expertise in process development, process scale-up and manufacturability for drug substance and intermediates as an integral part of route development. You will also act as a scientific expert to deliver our science and technology strategy and other improvement activities both internal and external to the Chemical Development department.

ESSENTIAL SKILLS/EXPERIENCE:

• A degree and / or PhD in Chemistry or Chemical Engineering.
• The ability to support multiple projects as a lead Particle Engineering scientist.
• Provide support for the development and delivery of intermediates and API particle processes internally & externally.
• Experience of development and manufacturing platforms for continuous particle forming processes or familiarity with modelling software (e.g. Aspen, DynoChem, gPROMS formulatedProducts) to support process design and understanding.
• Have the ability to work collaboratively with colleagues in Drug Product Development in multi- functional teams to define desired particle properties for formulations, manufacturability and bioavailability.
• Experience in a range of particle/materials characterisation techniques.
• Proficiency with inline Process Analytical Technology (PAT).
• Generating, reporting and interpreting high quality data with clear impact to development projects.
• Have the ability to independently represent the department and the Particle Engineering skill area within multi-functional teams.
• Ability to present information and engage in discussions in multi-disciplinary project teams.
• Effective communication and influencing skills.
• Continuously develop yourself and your colleagues via training and shared learning experiences to improve our efficiency and effectiveness.
• Ensuring own work is performed and recorded in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Manufacturing Practice (GMP).

DESIRABLE SKILLS AND EXPERIENCE:

• Experience of working in the Pharmaceutical or Fine Chemicals Industry.
• Involvement with working with Contract Development and Manufacturing Organisations (CDMOs).
• Involvement in the development and manufacturing of non-crystalline or large molecule entities.
• Knowledge of particle size reduction unit operations.
• Experience in technology transfer and commercial production.
• Experience of leading and driving improvement projects or new ways of working.
• Collaboration with external partners investigating a new technology or process and implementing these within an industrial setting.
  When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
  At AstraZeneca, we are driven by our commitment to deliver accelerated growth and to make people’s lives better. We are leading the way in delivering Lean processes that drive greater efficiency and speed. Sustainable practices are at the heart of what we do, ensuring we manage our environmental impact across all our activities and products. We have the ambition to be a performance driven network, combining focused execution with a harmonious team-spirit.
  Are you ready to make an impact on society through our sustainability goals?
  Join us at AstraZeneca where you can be a key contributor to Zero Carbon by 2025 and carbon negative across the entire value chain by 2030.
  Apply today

Join AstraZeneca, a global, innovation-driven biopharmaceutical company where we focus on the discovery, development and delivery of life-saving medicines. We are committed to sustainability and minimizing our environmental impact. We are currently seeking a Senior Scientist to join our vibrant Particle Engineering community within our Chemical Development department. As a Senior Scientist, you will be a scientific leader, working with teams across departments to design, develop, optimize and scale-up challenging processes.