Senior Scientist - PAT/Spectroscopy

at  Thermo Fisher Scientific

JOB DESCRIPTION

At Thermo Fisher Scientific, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on – now and in the future.
Within our Analytical Services team, we have a functional service provider solution, which is a unique partnership that allows our customers to leverage the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits.

EDUCATION AND EXPERIENCE:

• Bachelor’s degree in lab sciences such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology or similar
• Sr. Scientist: Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 4+ years’)
• OR Masters degree and previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 2+ years’)
• OR PhD
  In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.

KNOWLEDGE, SKILLS AND ABILITIES:

• Hands-on experience with evaluating and/or implementing PAT tools for real-time monitoring of bioreactor
• Experience using ML such as PCA, PLS, and clustering methods
• Experience developing and deploying chemometric models for quantitative analysis of bioreactor status
• Proficiency with scripting languages such as Matlab, Python or R and analytical softwares such as JMP, SIMCA, Unscrambler, etc.
• Familiarity with data visualization tools such as PowerBI, Spotfire
• Understanding of bioprocessing, gene therapy process development, characterization, and manufacturing
• Team player, innovative, collaborative, and initiative

• Evaluate and develop analytical methods for real-time monitoring of cell therapies using enabling technologies and traditional process analytical technologies
• Evaluate and develop on-line, in-line, or at-line analytical methods for process monitoring, in-process analytics, and process characterization
• Development of spectroscopic methods (Raman, NIR, FTIR) for process monitoring of biologics such as mAbs, proteins, viral vaccines, or gene therapy vectors. Preferred experience with cell therapy products
• Experience with in-line probes, such as capacitance and Raman spectroscope, and development of statistical and regression models using advanced data analytics
• Experience developing at-line or online methods using process automation, miniaturization, or high-throughput analytics
• Experience in professional capacity developing soft sensors and statistical process models using data science approaches such as ML and AI
• Familiarity or experience with robotic liquid handlers such as TECAN or Hamilton and their associated scripting software