Associate Scientist (In Vivo), Interventional Oncology

at  Johnson Johnson

Johnson & Johnson’s Interventional Oncology (INTO) is recruiting for an Associate Scientist (In Vivo) to join the Discovery Biology team in Beerse, Belgium.
At J&J, we are working to build a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease. We bring together the best minds and pursue the most promising science and we collaborate with the world for the health of everyone in it. Interventional oncology, which is a cross-sector initiative, is charged by the Executive Committee of J&J to alter the course of lung cancer and improving survival by preventing, intercepting, and curing lung cancer.
The successful candidate will join a dynamic, multi-disciplinary team of scientists in exploratory immuno-oncology, playing a key role in the evaluation and understanding of new drug concepts in vitro and in vivo.

Major Duties & Responsibilities

• Conduct methods of in vivo experimentation, including tumor implantation, dosing, proper handling of chemotherapeutics, radiotherapy treatment (SARRP), tumor measurement, health monitoring, and data collection and analyses.
• Conduct in vitro human and ex vivo mouse immunology experiments to support ongoing immune-oncology portfolio including assays using cancer cell, myeloid and T-cell based co-cultures. Tumor cell biology analysis including analysis of PDX lines and tumor dissociated material.
• Assist with design, execution, interpretation and reporting for in vivo syngeneic tumor model studies, to analyse efficacy of both intra-tumoral and systemic interventions.
• Application of diverse expertise in cellular and molecular biology (e.g. cell/organoid culture, compound screening, FACS, ELISA, western blotting, qRT-PCR, cell transfections & transductions, viral productions).
• Maintain detailed and organized experimental records and stay compliant on all relevant internal and external training requirements.
• Support discovery biology team with experimental set-up, assay optimization, analyze data using appropriate statistical methods and preparing data for presentation-ready format.

QUALIFICATIONS

• A minimum of a Bachelor’s degree in Life Sciences (such as Biology, Biochemistry, Pharmacology, Tumor Immunology) with a minimum of 6 months of laboratory-based experience in industry/biotech or an academic setting is preferred. OR a Master’s degree (M.S.) with relevant pharmaceutical or biotech industry/ lab/ academic experience is required.
• Experienced with animal handling in oncology-relevant rodent models such as subcutaneous and orthotopic tumor implantation techniques and dosing, proper handling of therapeutics, tumor measurement, health monitoring, and data collection and analysis required.
• Drug administration by subcutaneous, intraperitoneal, intravenous tail vein injections and oral gavage. Blood collection by tail vein, saphenous vein and cardiac puncture. Perform animal autopsy/dissection and microsurgery, perfusion and tissue collection.
• Experience with the adherence to animal welfare and compliance regulations is required.
• Experienced with cell culture of cancer or immune cells is preferred.
• Experienced with bioluminescent imaging, flow cytometry, IHC, ELISA is preferred.
• This position may require occasional weekend, evening, and holiday dosing/animal monitoring.
• Must have excellent interpersonal skills, with the ability to interact effectively with people.
• Must have strong organizational, data management, and record-keeping skills.
• The ability to handle several projects simultaneously is preferred.
• Must have excellent verbal and written communication skills in English
• Hiring will be contingent upon completion of laboratory animal research training courses accredited by the Federation of Laboratory Animal Science Associations (FELASA category B or C) or similar foreign certification.
• Knowledge of Microsoft Office and Graphpad Prism.
• Learning agility and ability to work across projects highly desirable
  Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com .
  This job posting is anticipated to close on May 24, 2024. The Company may however extend this time-period, in which case the posting will remain available on https://www.careers.jnj.com to accept additional applications

• Conduct methods of in vivo experimentation, including tumor implantation, dosing, proper handling of chemotherapeutics, radiotherapy treatment (SARRP), tumor measurement, health monitoring, and data collection and analyses.
• Conduct in vitro human and ex vivo mouse immunology experiments to support ongoing immune-oncology portfolio including assays using cancer cell, myeloid and T-cell based co-cultures. Tumor cell biology analysis including analysis of PDX lines and tumor dissociated material.
• Assist with design, execution, interpretation and reporting for in vivo syngeneic tumor model studies, to analyse efficacy of both intra-tumoral and systemic interventions.
• Application of diverse expertise in cellular and molecular biology (e.g. cell/organoid culture, compound screening, FACS, ELISA, western blotting, qRT-PCR, cell transfections & transductions, viral productions).
• Maintain detailed and organized experimental records and stay compliant on all relevant internal and external training requirements.
• Support discovery biology team with experimental set-up, assay optimization, analyze data using appropriate statistical methods and preparing data for presentation-ready format