Computational Medicinal Chemist/Senior Expert Data Science

at  Novartis

Preferred Experience:

• 2-5 years of experience working with project teams in a drug discovery environment

Skills and Abilities:

• Proactively anticipates project needs with a clinical focus.
• Demonstrates rigor and diligence in idea substantiation, analogue design, and experimentation.
• Strong team orientation with multitasking and adaptability in support and leadership roles.
• Effective listener with excellent written and oral communication skills.
• Proficient in data visualization to effectively communicate insights

ABOUT THE ROLE

Internal Title: Senior Expert I/II, Data Science
Location: Cambridge, MA on-site office, with occasional work from home
About the Role:
Join our vibrant and innovative Computer-Aided Drug Discovery (CADD) team in Cambridge, where we bring together diverse talents to redefine the way Biomedical Research discovery teams validate and develop new targets. We are a driving force behind drug discovery, and we are now eagerly searching for an outstanding computational scientist like you to join our ranks.
Imagine the opportunity to unlock hidden knowledge and disruptive insights from the vast and invaluable data collected by one of the world’s most renowned pharmaceutical companies. We need your expertise, experience, and unwavering passion to help us extract this wealth of information. Collaborating with a multidisciplinary group of scientists, you will be at the forefront of crafting inventive solutions to the most pressing drug discovery challenges, forging new paths toward groundbreaking medicines.
Are you ready to seize this outstanding chance to make a significant impact in the field of drug discovery? We invite you to embark on this thrilling journey with us, as we push the boundaries of what’s possible in scientific exploration. Join our team and be part of a revolution that will shape the future of medicine.
Together, we will transform the landscape of drug discovery, accelerate breakthroughs, and change lives. Apply now and let your expertise shine in our dynamic and forward-thinking environment.

Your Responsibilities Include:

• Drive the design of medicinal chemistry efforts by applying in-depth knowledge of structure-activity relationships (SAR), a profound understanding of target biology, and predictive methods for assessing on- and off-target activity, physical properties, pharmacokinetics/pharmacodynamics (PK/PD), and synthetic feasibility.
• Thrive at the intersection of experimental and groundbreaking digital technologies, with a particular emphasis on expertise in machine learning and artificial intelligence (AI) as applied to small molecule drug discovery.
• Stay abreast of scientific literature and engage with internal and external scientists to incorporate biological insights into lead characterization and screening initiatives.

Collaborate with interdisciplinary project teams to facilitate effective decision-making throughout the target identification to candidate nomination process. This involves applying and developing predictive models based on high-content and time-resolved screening data, including imaging techniques.

• Drive hypothesis generation to improve clinical success rates for programs involving small molecules, peptides, RNAs, protein degradation, molecular glues, transient covalent inhibitors, and kinetic stabilization of drug-target complexes.
• Take a leading role in cross-disciplinary mechanistic studies using physics-based modeling and simulation, biophysical characterization, and cellular validation. These studies will inform the strategic targeting strategies of discovery projects, aiming for optimal mechanisms of action (MoAs).

ROLE REQUIREMENTS

What You’ll Bring to the Role:

• Advanced degree in medicinal chemistry, computational chemistry, computational biology, computational chemical biology, or a related field. Candidates with a laboratory-based background in chemistry and biology, supplemented with strong computational experience, are also encouraged to apply.
• Proven track record of innovation through analogue design, leading to significant impact on discovery projects.
• Familiarity with drug design tools and high-performance computing environments and strong publication history in peer-reviewed journals.

Preferred Experience:

• 2-5 years of experience working with project teams in a drug discovery environment.

Skills and Abilities:

• Proactively anticipates project needs with a clinical focus.
• Demonstrates rigor and diligence in idea substantiation, analogue design, and experimentation.
• Strong team orientation with multitasking and adaptability in support and leadership roles.
• Effective listener with excellent written and oral communication skills.
• Proficient in data visualization to effectively communicate insights.

Why Novartis:
Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture
You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook: https://www.novartis.com/careers/benefits-rewards
Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams’ representative of the patients and communities we serve.
Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $130,400 to $216,000/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please let us know the nature of your request, your contact information and the job requisition number in your message:

• Novartis: e-mail us.reasonableaccommodations@novartis.com or call +1 (877)395-2339
• Sandoz: e-mail reasonable.accommodations@sandoz.com or call: +1-609-422-409