PhD student: unraveling the radiation biology of radioactive anticancer agents

at  Erasmus MC

PHD STUDENT: UNRAVELING THE RADIATION BIOLOGY OF RADIOACTIVE ANTICANCER AGENTS

The project focuses on investigating cellular effects of radioactive anti-cancer agents as part of a Dutch NWO-funded consortium.

• Closing date 11-04-2024

13.11.24.TDA

Job description

JOB DESCRIPTION

We are looking for a highly motivated PhD student to work on a project focusing on the radiation biology of targeted radionuclide therapy (TRT). This multidisciplinary project brings together expertise from the fields of nuclear medicine, molecular biology and cellular (radiation) biology.
TRT is a promising novel modality to treat patients with metastasized cancer. TRTs function via systemic administration of radiolabeled molecules designed to target tumor cells. However, the biological radiation effects of TRTs are poorly understood, and rational design of new modalities based on underlying cellular mechanisms is therefore not possible, resulting in suboptimal treatment strategies. In this preclinical research project, you will perform cellular experiments to identify and quantify specific radiobiological mechanisms of TRT-radiation effects.
In this project, you will be trained in using various laboratory techniques including cell culture, (fluorescent) microscopy, and different molecular biological techniques. Focus of this project will be on 2D cellular model systems and within the consortium, you will collaborate with colleagues from Radboud UMC who will work on 3D and in vivo radiobiology.
Work environment

QUALIFICATIONS AND SKILLS

• You are a highly motivated and talented candidate that holds a MSc degree in Biomedical Science, Molecular/Cellular Biology, Oncology, or related field with a basic knowledge on radionuclide/radiation treatments and/or the DNA damage response.
• Experience with standard molecular biology techniques, microscopy and/or radionuclide handling will be considered an advantage.
• You are a team-player who is able to combine independent thinking with a collaborative attitude as you will be working in a dynamic international research environment.
• You have strong written and oral English skills (EUR requirements minimum IELTS overall score of 7.0 [comparable to TOEFL PBT: 600; TOEFL CBT: 250; TOEFL IBT: 95]).
  Before you apply please check our conditions for employment.
  Terms of employment

Please refer the Job description for details