Post-Doctoral Associate

at  University of Minnesota

Required Qualifications:

• Must have PhD in medicinal chemistry with a strong emphasis in structural biology.
• Demonstrated experience working with international collaborators on crystallization of small

molecule compound complex with proteins and the solution of these structures using

computational methods.

• Knowledge of the processes for uploading data to the PBD (protein databank).
• Knowledge typically acquired by structural biology work in a rigorous academic setting.
• Detailed knowledge of the methods structural biology including plasmid design, protein

production and purification, and methods of protein-complex crystallization.

• Strong scientific writing skills.
• Superior record keeping and documentation skills.
• Excellent communication (both spoken and written) skills.
• Demonstrated ability to lead and complete complex projects.
• Demonstrated knowledge of chemical safety and chemical hygiene strategies.
• Demonstrated knowledge of typical software packages such as (but not limited to) Microsoft Office, ChemDraw, Graphpad Prism and software typically used by structural biologists in the solution of crystal structure data.
• Ability to work completely independently.
• Strong collaborative skills.

Preferred Qualifications:

• Experience in the design and expression of mutant proteins suitable for crystallization.

Provide structural biology support to ensure that translational medicinal chemistry projects in the Institute of Therapeutics Discovery and Development are advanced to milestones in an effective manner.
Job Duties/Responsibilities:

Laboratory-based Medicinal Chemistry (80%):

• Designs, plans, implements, and evaluates complex, multifaceted research projects in

structural biology while remaining current on technological and scientific developments in

the field and their potential application into experimental plans.

• Works with supervisor for experimental planning and executes scientific experiments to

sustain data generation and evaluation.

• Evaluates, suggest alternate methods, modify, or develop new procedures and techniques

to aid in the investigation of structural biology research problems or programs in the

supervisor’s laboratory.

• Modifies protein expression to maintain efficiency and quality, searches for better ways to

effectively achieve end results by, for example, scheduling work steps, arranging/ rearranging the way work is generally performed, and adding or deleting elements of

processes as necessary.

• Discusses and plans new avenues of research with supervisor. Will work under the general

supervision of her supervisor but has the discretion to make daily operational decisions and

work independently.

• Documents work appropriately in electronic laboratory notebooks. Ensures that structural

biology data prepared in the laboratory conform to the quality required for publication.

Writing and Editing: (15% of time):

• Assists with the preparation of scientific manuscripts and works with journal

editors/reviewers to insure effective publication.

• Assists in the drafting reports to communicate her work to the project team and to our

funding sources.

Safety: (5% of time):

• Adheres to best practices of safety and chemical hygiene as mandated by the Department of

Neurology and the Department of Medicinal Chemistry at the University of Minnesota.
Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.
Additional documents may be attached after application by accessing your “My Job Applications” page and uploading documents in the “My Cover Letters and Attachments” section.
To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-8647.
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The University of Minnesota, Twin Cities (UMTC)
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Please refer the Job description for details