Post-Doctoral Research Fellow - Arimura Lab

at  Fred Hutchinson Cancer Center

Overview:
Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.
With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.
At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion.
The Arimura Lab (Basic Sciences Division, Fred Hutch) was just launched in February 2024. We are looking for a Postdoctoral Fellow to help establish a diverse, innovative, and collaborative research team. The successful candidate must have a keen interest in chromatin biology and the courage to develop novel approaches, although no prior research experience in structural biology is required.
The mission of the Arimura Lab is to elucidate the regulation mechanisms of biological events occurring in eukaryotic chromosomes, such as the transcription regulation in euchromatin and heterochromatin, the mitosis-specific mechanisms that compact chromosomes and assemble kinetochores, and the accessible chromatin formation around transcription start site. Our Lab will accomplish this elucidation by developing novel approaches. The lab currently possesses unique technology to determine the high-resolution cryo-EM structures of chromatin-related complexes isolated from interphase and M phase chromosomes formed in Xenopus (frog) egg extract (PMID: 34478647) and Magnetic Isolation and Concentration (MagIC)-cryo-EM, a technique enabling direct structural analysis of targets captured on nanomagnetic beads, which allows for the structural determination of scarce macromolecules (< 0.0005 mg/mL: 100 to 1000-fold lower than conventional cryo-EM) in heterogeneous samples (PMID: 38328033 [preprint]). By using these unique technologies and further developing them, we elucidate the structural basis of the biological events on eukaryotic chromosomes.
The Arimura Lab provides a supportive environment that strongly emphasizes individualized mentoring. Upon joining, we will prioritize your continued development as an independent scientist. We will collaborate with you to identify and develop plans to achieve your research and professional development goals. In addition, Fred Hutch and the Basic Sciences Division offer numerous career development opportunities, benefits, and competitive salaries (starting at approximately $68k, with scheduled raises to ~$91k by 2027) for postdoctoral fellows.
Responsibilities:
The fellow will either work on implementing our unique technologies or further advancing them (e.g. combining them with genomics) to elucidate the structural basis of the biological events occurring in eukaryotic chromosomes. The fellow will record and present their work at group meetings and conferences and write up their work for publication. Secondary responsibilities include mentoring graduate students and research technicians and contributing positively to the lab community and intellectual environment.

Please refer the Job description for details