Postdoc positions available at reNEW Copenhagen Node in the lab of Josh Brickman

at  Kbenhavns Universitet

The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW) at Faculty of Health & Medical Science at the University of Copenhagen is looking for post-doctoral fellows to join the Brickman group starting September 1st or upon agreement. These positions will explore enhancer regulation in response to FGF/ERK signaling as a means to understand how transcription factors interface with signaling to regulate cell fate choice in early development as part of an ERC advanced grant program, “Signaling decoded in ENhanCEr states – a molecular basis for plasticity in development and differentiation (SENCE).” These positions can also be associated with a second project focused on a similar phenomena in Ventral Foregut derived from human pluripotent stem cells, where we have observed proliferation leads to the commissioning of appropriate enhancers and decommissioning of inappropriate ones.

JOB DESCRIPTION

We are looking for positions that will focus on different aspects enhancer function and regulation, the interface with signaling and how they are influenced by the cell cycle. As a post doc in the Brickman lab, you will be working in a field of stem cell and molecular biology. You will be part of an international interdisciplinary team of scientists focusing on understanding enhancer regulation, gene regulatory networks and exploiting these networks to develop new technologies for cell type specification in vitro. We work with in vivo and in vitro systems in both mouse and human. For this project, you will work with either mouse embryos, mouse, and human embryonic stem cell (ESCs), human Ventral Foregut stem cells, human hypoblast stem cells and three-dimensional synthetic models for human and mouse development.

QUALIFICATIONS

• An equivalent of a PhD in Developmental, Stem Cell or Molecular Biology and/or Bioinformatics.
• Experience with next generation sequencing technologies, ChIP-seq, CUT&RUN, single cell RNA-seq etc.
• Experience with computational analysis of next generation sequencing datasets.
• Experience with embryonic stem cell culture.
• Experience with proteomics or phosphoproteomics.
• Molecular biology, western blots, RT-PCR etc.
• English communication skills, both oral and written are a must.

• To implement state of the art genomic and proteomic technologies to understand the basis of enhancer activity in early development and differentiation.
• To develop new approaches to identify enhancer specific co-factors involved in signaling response.
• To define regulatory networks and signaling response.
• To optimize new molecular and biochemical approaches to single locus and single molecule functional assays.
• Will be expected to be competitive for and write independent research fellowships.