Postdoctoral Fellow PhD- Development and Disease

at  Baylor College of Medicine

SUMMARY

The Tom Cooper lab at Baylor College of Medicine has open projects that investigate that investigate two related areas: (1) the mechanisms and physiological consequences of conserved alternative splicing transitions regulated during mammalian postnatal development and (2) the disruption of this regulatory network that is the pathogenic mechanism of the microsatellite expansion disease myotonic dystrophy type 1 (DM1) that affects multiple tissues and is the most common cause of muscular dystrophy in adults. In DM1, the RNA expressed from the expanded allele disrupts regulation of a network of alternative splicing transitions that normally drive fetal to adult protein isoform expression. Expression of fetal protein isoforms unable to perform the functions required in adult tissue causes disease features. The investigations in these two areas are complementary and provide the basis for an exchange of ideas and collaboration within the lab.

MINIMUM QUALIFICATIONS

• Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.
  Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer

• Plans, directs and conducts research experiments related to gynecological pathologies.
• Collects, analyzes, and documents experiment results.
• Performs different cell and molecular biology studies using mice and immortalized cells.
• Documents results of experiments and reports to principal investigator.
• Conducts literature searches and summarize information for ongoing projects.
• Works with others in the lab and other groups as part of collaborations.
• Maintains mouse colonies.
• Performs molecular biology and cell biology experiments.