Postdoctoral Scholar- Hoffmann Lab

at  Gladstone Institutes

Category:
Postdoc
Lab/Area:
Hoffmann Lab
Description:
Postdoctoral Scholar – Hoffmann Lab
Who we are:
The Gladstone Institutes is an independent, not-for-profit research institution. Its mission is to improve the health and well-being of all people through medical research and education in neuroscience, cardiovascular biology, immunology, and stem cell biology. Home to notable leaders in science and biomedicine, Gladstone comprises five institutes as well as various centers and programs. All of its approximately 600 members are aligned in their mission to carry out or support science that overcomes disease. Located in an award-winning building at the Mission Bay Campus, Gladstone offers a competitive salary and benefits program. It provides an ideal environment for those seeking to maximize and fully leverage their potential. Consider Gladstone and make a difference in human health.
About the role:
The Hoffmann Lab at the Gladstone Institute of Virology is seeking a highly skilled and motivated individual to join our dynamic team as a Postdoctoral Scholar. The focus of research in the Hoffmann Lab is the development of mRNA- and nanoparticle-based vaccine technologies against a wide range of infectious diseases (see Hoffmann et al., Cell, 2023;
https://doi.org/10.1016/j.cell.2023.04.024
) and cancer, as well as gaining a deeper understanding of the immunological mechanisms that shape vaccine-induced immune responses. Additional research directions focus on the development of nanoparticle-based drug delivery systems for mRNA- and small molecule-based therapeutics, and global interactome screening platforms to map interactions between cell surface proteins and identify new drug targets. The successful candidate will work on research projects in these areas depending on their interests and background, and become a member of our vibrant and collaborative research team.

What you will do:

• Design, execute, and analyze experiments, both independently and in collaboration with other team members and external research collaborators
• The research projects leverage multidisciplinary expertise in molecular biology, immunology, virology, and bioengineering including:
• Design and characterization of immunogens and self-assembling nanoparticle systems
• Development and evaluation of mRNA- and protein nanoparticle-based vaccine candidates and technologies for a wide range of infectious diseases
• Analysis of vaccine-induced cellular and humoral immune responses using a variety of methods
• Development and application of high-throughput screening and in vitro evolution methodologies for various applications
• Present research findings at group meetings and external conferences
• Maintaining accurate records and organized records of experimental procedures and results
• Collaborate with team members on various research projects
• Contribute to training/supervision of students and research associates in the lab.

What you will need:

• PhD in Biology, Molecular Biology, Microbiology, Immunology, Chemistry, Bioengineering, or related field
• Some background in protein engineering, immunology, virology, and/or assay development
• Excellent laboratory skills
• Excellent communication skills (oral and written)
• Ability to work in a team environment

What is preferred:

• Strong background in protein engineering, immunology, virology, and/or assay development
• Excellent productivity and publication record
• High level of creativity and organizational skills
• Ability to work on several projects in parallel as part of a team
• Strong interpersonal skills and the ability to work effectively with individuals from diverse backgrounds

If this role is not for you:
Please stay in touch and to see a complete list of our open career opportunities, please visit:
https://gladstone.org/careers
Hiring Range:
See postdoc scale:
https://gladstone.org/training/postdocs

Gladstone Perks & Benefits

• People–work with talented, committed, and supportive teammates within an organization that values each member of its community.
• A meaningful place to grow and learn–whether it’s your professional skills or scientific knowledge, we have the resources and environment to advance either so you can better support Gladstone’s mission to drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and diverse environment.
• Healthy work/life balance–you are highly engaged and productive at work because you can have time to recharge and enjoy a vibrant life outside of work.
• Compensation–competitive salary. Title and salary will be commensurate with education and experience.
• Excellent benefits–generous medical, dental, vision, retirement plan, paid vacation, commuter benefits, access to free shuttle transportation.

Gladstone is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, sex, religion, national origin, ancestry, age, marital status, medical condition, physical or mental disability, veteran status, sexual orientation, or any other non-job related characteristic. We make all employment decisions so as to further this principle of equal employment

• Design, execute, and analyze experiments, both independently and in collaboration with other team members and external research collaborators
• The research projects leverage multidisciplinary expertise in molecular biology, immunology, virology, and bioengineering including:
• Design and characterization of immunogens and self-assembling nanoparticle systems
• Development and evaluation of mRNA- and protein nanoparticle-based vaccine candidates and technologies for a wide range of infectious diseases
• Analysis of vaccine-induced cellular and humoral immune responses using a variety of methods
• Development and application of high-throughput screening and in vitro evolution methodologies for various applications
• Present research findings at group meetings and external conferences
• Maintaining accurate records and organized records of experimental procedures and results
• Collaborate with team members on various research projects
• Contribute to training/supervision of students and research associates in the lab