Principal Research Associate, Analytical Development

at  Moderna

HERE’S WHAT YOU’LL BRING TO THE TABLE:

BS with at least 5 years or MS with at least 2 years of relevant industry experience in analytical development or in the small-molecule biopharmaceutical space.
BS/MS in Chemistry, Analytical Chemistry, Biochemistry, or closely related field.
Practical experience with HPLC, CE, GC, and MS method development, validation, and transfer.
Experience with sample extraction/separation techniques and chromatography methods (SPE, SPME, RP-IP, HILIC, SEC, etc.).
Knowledge of nucleic acid chemistry and biology and standard methods of analysis of these molecules.
Knowledge of theories, principles and techniques of relevant scientific areas and basic understanding of industry practices and standards.
Excellent communication (oral and written) and attention to detail
Ability to follow complex method development and suggest appropriate method modifications
Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies
Strong interpersonal skills with an eagerness to work with and support colleagues in other departments.
(Preferred) Knowledge of current FDA and ICH guidance’s
Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:
Highly competitive and inclusive medical, dental and vision coverage options
Flexible Spending Accounts for medical expenses and dependent care expenses
Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
Family care benefits, including subsidized back-up care options and on-demand tutoring
Free premium access to fitness, nutrition, and mindfulness classes
Exclusive preferred pricing on Peloton fitness equipment
Adoption and family-planning benefits
Dedicated care coordination support for our LGBTQ+ community

THE ROLE:

Moderna is seeking highly skilled, talented, and motivated applicants for a Principal Research Associate position based in Norwood, MA site. This role will support Analytical Development with method development/pre-validation, impurity identification and characterization of small molecule/lipid components of mRNA-Lipid Nanoparticles (LNP) based pharmaceuticals. The individual will work with other scientists and interface with Process Chemistry, Preformulation, and Strategy teams. The successful candidate must have a strong background in method development, separation sciences, and mass spectrometry. Experience with the analysis of small molecules such as lipids and polymers are preferred.
This role will be located at the Moderna Technology Center in Norwood, MA.

HERE’S WHAT YOU’LL DO:

Contribute as part of the Analytical Development towards the development and execution of various separation and mass spectrometry based analytical methods to support raw materials, lipids, RNA, drug substance and drug product characterization, impurity identification, release, and stability.
Perform method development, qualification, validation, and support method transfer and associated documents to internal QC and external CROs/CMOs.
Focus on development and execution of separations science for the profiling, characterization, and quantification of small molecules and lipids using UHPLC-CAD/MS and GC-FID/MS
Work closely with colleagues within Moderna Process Chemistry, Process Development, Formulation, Analytical Tech Operations, Analytical Sciences and Technology and QC teams to support raw material testing, process optimization, method development, forced degradation studies and hands-on troubleshooting.
Demonstrate independent judgment in technique and method selection, study design, generate and contribute to data analysis, technical report writing and presenting findings to multidisciplinary teams.
Maintain a safe laboratory work environment and be accountable for good documentation practices.