Process Engineer

at  Cellistic

The mission of Cellistic/ Ncardia Belgium is to understand human iPSC and developmental biology and harness this knowledge to develop and manufacture iPSC therapeutics that significantly improve patient outcomes. We are convinced that pluripotent stem cell technology is the key to getting better, more efficient treatments to patients faster. To achieve this mission, we are building a world-leading research facility to overcome the complexity and challenges of iPSC lineage specification. We will know we have succeeded when we can reliably and rapidly generate cell products that consistently produce positive outcomes in patients. For more information about the company, please visit our website at www.cellistic.com
Within our MSAT team in Mont-saint-Guibert (Belgium) there is one position immediately available for a Process Engineer.
You will join an international and dedicated group of scientists, project leaders and laboratory technicians. We have expertise in bioprocess development, stem cell biology, cell-based assays, and GMP manufacturing. If this awakens your interest, please apply and support us to achieve our mission in bringing better therapies to patients faster.

QUALIFICATION & EXPERIENCE

• Ph.D. and 10+ years or MS and 15+ years of experience in bioengineering, chemical engineering, biology, biochemistry or related field
• Must have industry and project management experience; direct, hands-on industrial upstream experience (ideally in gene and/or cell therapy process development),
• Strong industrial upstream processing knowledge required from a small-scale cell culture process development perspective
• Industrial experience with biologics, gene and/or cell therapy upstream process development including ownership of key process decisions. Prior experience with different modes of cultivation such as fed batch and perfusion (ATF, TFF, G-rex) desired
• Prior experience with primary cells, T or NK cell culture, stem cells (including hematopoietic stem cells), and /or stem cell differentiation desired
• Strong organizational, troubleshooting and interpersonal skills along with excellent oral and written communication
• Demonstrated ability to work in a fast-paced, collaborative, and matrixed organization environment.
• Ability to work a flexible schedule as weekend work is required
• Since we are working in an international environment; proficiency in English, both written and spoken, is a prerequisite.
• As a person, you are open-minded and a good communicator by nature. You have a high level of energy that drives you and inspires your colleagues. You thrive in a changing and dynamic work environment, and in a job that requires you to be flexible, take initiatives and think out of the box when challenges occur. You are a true team-player who enjoys working in close collaboration with colleagues in and out of the laboratory.

• Develop pioneer processes and introduce state-of-the-art technologies to manufacture iPSC-derived T-cells therapeutics.
• Evaluate and implement technology to improve consistency, increase scalability, and improve cGMP compliance of bio-processes for manufacturing iPSC-derived T-cells therapeutics.
• Leverage high throughput experimental designs and equipment (from deep well plates to small scale bioreactors) to optimize cellular differentiation and optimize for product quality
• Develop scale-down models for process optimization studies.
• Evaluate and implement process analytic technologies (PAT) for improved monitoring and control of stem cell bio-processes.
• Responsible to plan technical work packages and deliver them according to quality and delivery targets, in alignment with the project manager.
• Write protocols, technical reports, and Standard Operating Procedures (SOPs).
• Participate in technology transfer of processes and equipment to the Manufacturing group.
• Collaborate with project teams to integrate processes.
• Ability to manage various priorities in a fast-paced and growing environment
• Document, share, present and communicate study results at meetings and in other formats