Research Assistant

at  Stanford University

Stanford University is seeking a Life Science Research Professional 1 to perform basic functions and activities involved in defined research projects, and independently conduct and analyze experiments. Work will be conducted in a laboratory whose primary focus is the discovery of cellular signaling mechanisms that serve as a basis for developing novel therapeutic approaches for Alzheimer’s disease, Huntington’s disease and other neurological disorders. The LSRP will be primarily responsible for administering experimental therapeutic compounds to mice via intraperitoneal injections and oral gavage, maintaining mouse breeding logs and colony databases, and assisting in behavior testing and pathological analysis of various mouse models of neurodegenerative diseases. The LSRP will independently run experiments after consultation with a supervisor and will help modify existing techniques and procedures. The LSRP will be responsible for a variety of tasks including preparing tissue for histological analysis, immunostaining, microscopy, and statistical analysis of data. The LSRP will also be responsible for maintaining detailed experimental records and will provide technical support and training to other laboratory personnel.

DESIRED QUALIFICATIONS:

• Prefer a degree in the Biological Sciences.
• He/she must have experience in handling small animals and conducting assessments of transgenic mice using molecular biology and other approaches. The job requires someone who is meticulous and highly organized.
• Proficiency in Western Blotting, ELISA, histology, immunostaining, multiplexed protein assays, light and confocal microscopy.
• Computational experience with R and bash processing.
• Computer experience with spreadsheet and word processing applications.
• Experience or willingness to learn quantitative analysis of brain tissue images.

EDUCATION & EXPERIENCE (REQUIRED):

Bachelor’s degree in related scientific field.

KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):

• General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.
• Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.
• Ability to maintain detailed records of experiments and outcomes.
• General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
• Ability to work under deadlines with general guidance.
• Excellent organizational skills and demonstrated ability to accurately complete detailed work.

PHYSICAL REQUIREMENTS*:

• Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
• Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
• Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
• Must have correctible vision to perform duties of the job.
• Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
• Ability to lift heavy objects weighing up to 50 pounds.
• Ability to work in a dusty, dirty, and odorous environment.
• Position may require repetitive motion.
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• Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

• Plan approach to experiments in support of research projects in lab and/or field based on knowledge of scientific theory.
• Independently conduct experiments; maintain detailed records of experiments and outcomes.
• Experiments involving handling small animals, administering experimental therapeutics and evaluating brain. pathology via immunostaining, Western blotting and other histological/biochemical approaches. Interpret and perform basic analyses of results. May also include processing of large data sets including RNAseq.
• Apply the theories and methods of a life science discipline to interpret and perform analyses of experiment results; offer suggestions regarding modifications to procedures and protocols in collaboration with senior researcher.
• Review literature on an ongoing basis to remain current with new procedures and apply learnings to related research.
• Contribute to publication of findings as needed. Participate in the preparation of written documents, including procedures, presentations, and proposals.
• Help with general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed.
• Assist with orientation and training of new staff or students on lab procedures or techniques.
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• Other duties may also be assigned.