Research Fellow in Molecular Modelling/Computational Chemistry

at  Coventry University

QUALIFICATIONS REQUIRED

Applicants should have, or have already submitted a PhD in computational chemistry, computational biology, molecular modelling or related disciplines.

Applications are invited Postdoctoral Research Fellow in computational chemistry and molecular modelling to investigate the enzymatic regulation of the post-translational modification (PTM) S-acylation. The successful applicant will join the groups of Dr Jennifer Greaves, Dr Giuseppe Deganutti and Professor Chris Reynolds at the Research Centre for Health & Life Sciences, at Coventry University.
S-acylation (also called ‘palmitoylation’) is a prevalent post-translational modification involving the reversible attachment of fatty-acyl groups to proteins and acts as a molecular switch to regulate protein function spatiotemporally. Disrupted S-acylation is linked to human disease, including cancer, neurological disorders, and diabetes. Metabolic serine hydrolase enzymes are key components of dynamic protein S-acylation, however relatively little is known about their role in S-acylation pathways. The successful applicant will conduct in silico biomolecular simulations to understand the structural basis of dynamic S-acylation. This 16-month post funded by UKRI will provide the researcher with excellent training and developmental opportunities to support future career progression.