Research Fellow

at  Mass General Physicians OrganizationMGPO

JOB SUMMARY:

The Manstein Laboratory at Massachusetts General Hospital is conducting research in dermatology, focusing on the development of novel, energy-based procedures for the treatment of various skin conditions, including scars, burns, aging skin, and fat removal. We are inviting applications for a dedicated and innovative Research Fellow with a strong foundation in Molecular Biology and Immunology. This position requires the successful candidate to contribute to our ongoing projects by designing and executing experiments, analyzing complex data sets, and publishing findings through scientific communication. The role requires expertise in molecular biology and immunology techniques to be applied in a dermatological context.

REQUIREMENTS:

• A Ph.D. in Molecular Biology, Biochemistry, or a closely related field, with coursework or research experience in Immunology.
• Demonstrable experience in molecular biology techniques (e.g., PCR, RT-qPCR, Western blotting, CRISPR-Cas9, RNA sequencing).
• Familiarity with immunological assays and concepts, particularly those relevant to dermatological research.
• Proven track record of conducting animal studies, preferably with experience in mouse models, including handling, surgery, and post-operative care.
• Solid understanding of data analysis software and bioinformatics tools relevant to molecular biology and immunology.
• Exceptional written and verbal communication skills, with the ability to present complex data to diverse audiences.
• Capacity to work both independently and collaboratively within a multidisciplinary research team.

PREFERRED QUALIFICATIONS:

• Previous experience with laser-based devices or photochemical assays.
• Background in dermatological research or a keen interest in dermatology and skin biology.
• Evidence of successful publication in peer-reviewed journals.
• Ability to manage multiple projects and adapt to shifting priorities in a research environment.

PROJECT DESCRIPTION:

Building upon the foundational insights gained from exploring immune checkpoint inhibitors (ICIs) and the novel use of ablative fractional photothermolysis (aFP) in oncology, our next project seeks to unify and expand upon these strategies to address the challenge of neoantigen-deficiency in cancer treatment. By integrating the mechanisms through which ICIs leverage the immune system’s ability to recognize and combat tumor-specific neoantigens with the potentiation of immune responses observed with aFP, combined with immune modulators such as anti-PD-1 antibodies and OX40 agonists, we aim to create a comprehensive approach that induces robust anti-tumor immunity across a broader spectrum of cancer types. This project will explore the synergy between these modalities to promote epitope spreading and enhance the immunogenicity of tumors traditionally considered non-responsive to current immunotherapies. Through detailed molecular and cellular analyses, alongside innovative in vivo models, we will investigate the potential for this combined therapy to generate tumor remissions, even in the absence of high neoantigen burdens, by fostering an immune environment that supports the development of memory responses against tumor-lineage self-antigens. This research represents a significant step towards developing universal strategies for cancer immunotherapy, potentially transforming the treatment landscape for patients with neoantigen-deficient malignancies.

PREFERRED QUALIFICATIONS:

• Previous experience with laser-based devices or photochemical assays.
• Background in dermatological research or a keen interest in dermatology and skin biology.
• Evidence of successful publication in peer-reviewed journals.
• Ability to manage multiple projects and adapt to shifting priorities in a research environment.
  EEO Statement
  Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.
  Primary Location MA-Charlestown-MGH 529 Main
  Work Locations MGH 529 Main 529 Main Street Charlestown 02129
  Job MD/PHD/Fellows/ PostDocs
  Organization Mass General Physicians Organization(MGPO)
  Schedule Full-time
  Standard Hours 40
  Shift Day Job
  Employee Status Regular
  Recruiting Department MGH Cutaneous Biology Research Center
  Job Posting Apr 3, 2024

• Conduct high-level research into molecular mechanisms underpinning skin health, disease, and treatment outcomes, focusing on cellular and molecular biology and immunology techniques.
• Implement molecular biology techniques to explore the genetic and epigenetic contribution involved in skin conditions, leveraging knowledge of immunology to understand inflammatory responses and healing processes.
• Utilize and develop in vitro and in vivo models, including mouse models, to study the effects of novel dermatological treatments.
• Employ a variety of molecular and cellular assays to assess treatment efficacy, mechanism of action, and safety profiles.
• Collaborate closely with a multidisciplinary team to integrate molecular findings with clinical insights, aiming to translate research into tangible medical device solutions.
• Stay in touch with the latest scientific advancements in molecular biology, immunology, and dermatology to inform experimental design and innovation.
• Contribute to the drafting and submission of research manuscripts for publication in high-impact journals and prepare grant proposals to secure funding.
• Engage in knowledge exchange within the lab and broader scientific community, presenting research outcomes at conferences and workshops.