Research Technician

at  Springer Nature

RESEARCH TECHNICIAN

Employer
University College London (UCL)
Location
London, England
Salary
Negotiable
Closing date
26 Apr 2024
Discipline
Health Science
Job Type
Researcher
Employment - Hours
Full time
Duration
Fixed term
Qualification
Undergraduate
Sector
Charity/NGO

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ABOUT US

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.
The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.
Tim Bartels first discovered disease resistant forms of the α-synuclein protein and their destabilisation in Parkinson’s Disease. His lab is interested in identifying the different factors that destabilise α-synuclein and that lead to neurotoxicity.

We’re now offering an exciting opportunity to join the lab as a Research Technician to provide experimental support for the research project, which will comprise the analysis of human postmortem brain material and various cell culture models including iPSC-derived and primary human neurons as well as structural in vitro assays using recombinant protein. The native brain tissue and the in vitro models will be used to study α-synuclein multimers and lipid composition in different Synucleinopathies. In vitro, aggregation assays, electron microscopy, CD spectroscopy, and FCS will be used to elucidate context-dependent folding.
Technical assistance is required with histopathology techniques, biochemical analysis such as crosslinking and Western Blot, RNA and DNA analysis and cell culture, as well as protein expression and purification.
The post is available from 01 August 2024 and funded by the UK DRI at UCL for one year in the first instance.
Informal enquiries regarding the role can be addressed to Tim Bartels ().