Senior/Principal Scientist - Bispecific Development

at  TCypher Bio

T-Cypher Bio
Senior/Principal Scientist - Bispecific Development
T-Cypher Bio is an early-stage, innovative biotechnology company aiming to unlock an expansive target space to build a pipeline of novel, T-cell receptor (TCR)-based therapeutics. We are seeking a highly motivated Senior or Principal Scientist with a strong background in bispecific protein production to advance our platform development as part of the Protein Engineering team.

WHAT YOU WILL DO

The primary focus of this role will be to execute experiments for the production, purification, screening & characterization of novel bispecific formats. The ideal candidate should have hands on experience with bispecific protein production and demonstrate a strong understanding of protein engineering and molecular biology-based methods.

KEY RESPONSIBILITIES

• Develop T cell receptors for clinical use in advanced modalities such as bispecific immune cell engagers, TCR-like antibodies or ADCs.
• Drive the design, engineering, and characterization of TCR-based proteins using cutting-edge molecular biology techniques, protein engineering methodologies, and structural biology approaches.
• Produce, purify & characterize molecules, ensuring high purity and integrity for downstream assays.
• Develop and optimize assays for the identification, characterization, and quantification of novel formats
• Participate in group and project meetings, offering insights and expertise on technical elements to advance research projects
• Analyse and record experimental results and communicate findings to the team and to management
• Maintain and implement good laboratory practices, including accurate laboratory notebook systems, instrument and reagent maintenance, and personnel safety precautions.
• Work in a fast-paced start-up environment, with the motivation to work on multiple projects in parallel