JOB DESCRIPTION

At Thermo Fisher Scientific, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on – now and in the future.
Thermo Fisher’s clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission – to enable our customers to make the world healthier, safer, and cleaner.
Within our Analytical Services team, we have a functional service provider solution, which is a unique partnership that allows our customers to leverage the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits.

EDUCATION AND EXPERIENCE:

• Bachelor’s degree in lab sciences such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology or similar
• ARS: Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable 6+years’)
• OR Masters degree and previous experience that provides the knowledge, skills, and abilities to perform the job (comparable 4+ years’)
• OR PhD and previous experience that provides the knowledge, skills, and abilities to perform the job (comparable 2+ years)
  In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.

KNOWLEDGE, SKILLS AND ABILITIES:

• Extensive experience in LC-MS method development and sample testing. Experience in analyzing LC-MS data, especially RNA analysis is preferred.
• Extensive experience in MS data analysis.
• Prior experience with LNP, lipid, and/or RNA highly desired.
• Experience in Waters Acuity Premier UPLC System and Thermo Fisher Orbitrap Exploris 240 Mass Spectrometer
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• Proficiency in data analysis software ( e.g., Xcalibur, Chromeleon, Empower, etc.)

• Develop advanced and robust LC-MS analytical methods on mRNA payload identity (1) 5’ Cap identity and capping efficiency, (2) mRNA sequence and chemical modification identity (3) 3’ poly(A) tail length and identity
• Optimize the RNA biochemical assays to digest mRNA to evaluate 5’ Cap structure in order to generate high quality and coverage MS1 and MS2 data
• Test optimized RNA digestion and LC-MS protocols on commercially available mRNA and in-house made mRNA payloads
• Review and process complex LC-MS data using analysis workflow such as BioPharma Finder, interpret result, build data visualizations, and communicate results to team
• Train team members on sample preparation, LC-MS data generation/analysis, troubleshooting RNA LC-MS analysis
• Sample testing for lipid raw materials, protein ligands, and LNP formulations
• Present the findings to the GEnD team and the disease project team to inform decision making and next steps
• Maintaining RNA LC-MS instrument and order reagents and supplies as needed
• Maintaining/document records of all experiment including methods, experimental results, and report accordingly into electronic laboratory notebooks
• Skills and experiments in other additional mRNA analytics are a plus (eg HPLC, CE etc)